Table 5.
Sensitivity analysis of the association between the pre-miR-27a-rs895819 A>G polymorphism and risk of having a high alcohol intake 1.
| Variable | % Drinker High 2 | Risk 3 | ||||
|---|---|---|---|---|---|---|
| Sex | AA + AG | GG | p 4 | OR | 95% CI | p 5 |
| Men (n = 368) | 13.0% | 30.0% | 0.011 | 2.84 | (1.12–7.17) | 0.028 |
| Women (n = 639) | 2.9% | 10.7% | 0.003 | 3.79 | (1.36–11.64) | 0.012 |
| p 6 for interaction: | 0.774 | |||||
| Variable | % Drinker High 2 | Risk 3 | ||||
| Obesity | AA + AG | GG | p 4 | OR | 95% CI | p 5 |
| Non-obese (n = 495) | 8.2% | 21.0% | 0.005 | 3.31 | (1.34–8.18) | 0.010 |
| Obese (n = 512) | 5.1% | 13.6% | 0.022 | 3.87 | (1.21–12.35) | 0.022 |
| p 6 for interaction: | 0.934 | |||||
| Adherence to MedDiet | AA + AG | GG | p 4 | OR | 95% CI | p 5 |
| Low < 9 (n = 511) | 5.1% | 17.1% | 0.002 | 4.56 | (1.71–14.34) | 0.003 |
| High ≥ 9 (n = 496) | 8.2% | 17.8% | 0.033 | 2.49 | (0.09–6.60) | 0.069 |
| p 6 for interaction: | 0.546 | |||||
| Variable | % Drinker High 2 | Risk 3 | ||||
| Diabetes | AA + AG | GG | p 4 | OR | 95% CI | p 5 |
| No (n = 539) | 9.0% | 24.5% | 0.001 | 3.56 | (1.54–8.23) | 0.003 |
| Yes (n = 468) | 3.9% | 8.1% | 0.221 | 2.06 | (0.52–8.18) | 0.304 |
| p 6 for interaction: | 0.547 | |||||
| Variable | % Drinker High 2 | Risk 3 | ||||
| Hypertension | AA + AG | GG | p 4 | OR | 95% CI | p 5 |
| No (n = 163) | 8.0% | 23.1% | 0.103 | 4.59 | (0.77–27.59) | 0.096 |
| Yes (n = 844) | 6.4% | 16.4% | 0.004 | 3.22 | (1.50–6.90) | 0.003 |
| p 6 for interaction: | 0.818 | |||||
1 OR and 95% CI were estimated by multivariable logistic regression models adjusted for the covariates indicated below; 2 % of subjects having a high alcohol intake (>26.4 g/day in men and >13.2 g/day in women) depending on the pre-miR-27a-rs895819 polymorphism; 3 OR of being a high alcohol drinker in comparison with non-drinker + moderate, depending on the variable considered for GG individuals versus AA + AG (recessive model); 4 unadjusted p-value for comparison of percentages; 5 model adjusted for sex, age, type 2 diabetes, hypertension, dyslipidemia, obesity, smoking, physical activity and total energy intake; 6 p-value for the interaction term between the corresponding variable (sex, obesity, adherence to MedDiet, diabetes or hypertension) and the pre-miR-27a-rs895819 polymorphism (recessive) in the multivariable adjusted model.