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. 2016 Aug 18;17(8):1351. doi: 10.3390/ijms17081351

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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(Upper panel) miR-331-3p down-regulates NRP2, a putative direct target of miR-331-3p, and inhibits cell proliferation by regulating the expression of E6/E7, keratinocyte differentiation, cell cycle, and apoptosis in cervical cancer cells (thin black arrows); (Lower panel) HPV infection promotes cell proliferation through up-regulation of E6/E7, p16 and p63, and progression to cervical cancer (thin blue arrows). miR-331-3p acts as an anticancer factor through suppression of NRP2 (the thick blue arrow).