Table II.

Modulators of IDOLDH activity

[(−)-Ipsdienol] (μM)	Inhibitor	[Inhibitor] (μM)	Specific activity (nmol·min−1·mg−1)		KI
			without inhibitor	with inhibitor
16 a	Ipsdienone	16	0.308	0.246	29 μM
16	Ipsdienone	16	0.650	0.573	15 μM
4	(−)-Menthone	16–35	0.330	0.228	30 μMb
16	1-Propanol	33,300	0.308	0.126	33.6 mM
16	2-Propanol	33,300	0.308	0.441	9.9 mM
10	β-Estradiol	39	0.981	0.783	25 μMc
16	1,3-Butanediol	16	0.213	0.245	—
16	8β,9α Ryanoid	16	0.194	0.195	—
16	10-Epi ryanoid	16	0.194	0.197	—
16	Nerol	16	0.182	0.197	—
16	Geraniol	16	0.182	0.207	—
16	Citral	16	0.182	0.203	—
16	(+)-Ipsdienol	16	0.396	0.389	—

^aSample contained 25 mM NADP instead of 2.5 mM NADP

^bAverage value obtained from experiments with variable (−)-menthone concentrations

^cExperiment done once.