Fig. 4.

Illustration of the shuffles and sliding moves along sequences that are used to generate new offspring sequences from a parent. The top row illustrates swaps between two positions and the bottom row illustrates a combination of swaps and sliding. The latter to refers to changes to the positions of residues by sliding them over either to N- or C-terminal positions. Note that in the swap and slide move that the longer arrows signifies a residue being moved over an immutable residue.