Figure 4.

Percentage type 1 diabetes progression by PI:C ratio quartile. A: Percentage of all subjects whose conditions progressed to diabetes for each PI:C ratio quartile. Cochran-Mantel-Haenszel χ² test revealed a progressively increased likelihood of progression to type 1 diabetes with increasing PI:C quartile overall (P = 0.02). For Quartile (Q) 1 n = 30, for Q2 n = 29, for Q3 n = 29, for Q4 n = 30. B: Percentage of subjects in each age category progressing to diabetes for each PI:C ratio quartile. Cochran-Mantel-Haenszel χ² test revealed a significant association in the group of subjects ≤10 years of age (P = 0.02) but not in the group of subjects 11–18 years of age (P = 0.10) or >18 years of age (P = 0.91). For subjects ≤10 years of age: Q1 n = 14, Q2 n = 8, Q3 n = 6, Q4 n = 10. For subjects 11–18 years of age: Q1 n = 6, Q2 n = 6, Q3 n = 16, Q4 n = 13. For subjects >18 years of age: Q1 n = 10, Q2 n = 15, Q3 n = 7, Q4 n = 7.