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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Int J Cardiol. 2016 May 13;218:206–211. doi: 10.1016/j.ijcard.2016.05.015

Table 1.

Clinical characteristics and haemodynamics of all PAH patients (n=140), subgroup who had RV pressure analysis (n= 84) and control subjects with mPAP <25mmHg (n=22)

all PAH
patients
Patients with RV pressure trace
analysis
p value*
N=140 PAH n=84 Controls n=22
Age years 55 ± 16 55 ± 16 58 ± 14 0.518
Sex % female 66 64 64 1.00
Aetiology % (n)
  IPAH/FPAP 53.6 (75) 63 (53)
  CTDPH 37.9 (53) 31 (26)
  POPH 6.4 (9) 5 (4)
  HIV 1.4 (2) 0
  CHD 0.7 (1) 1 (1)
Therapy % (n)
  PDE5i 51.4 (72) 59.5 (50)
  ERA 35 (49) 28.6 (24)
  Prostanoid 5.0 (7) 1.2 (1)
  CCB 2.1 (3) 1.2 (1)
  Dual 6.4 (9) 9.5 (8)
mPAP mmHg 48 ± 13 50 ± 13 18 ± 4 <0.001
RAP mmHg 7 ± 6 8 ± 6 3 ± 2 <0.001
PVR Wood units 11.8 ± 5.8 12.2 ± 5.9 2.1 ± 0.9 <0.001
CI L/min/m2 2.2 ± 0.6 2.2 ± 0.7 3.0 ± 0.8 <0.001
SV/PP mL/mmHg 1.03 ± 0.5(138) 0.99 ± 0.4(82) 3.7 ± 1.5 <0.001
RVEF % 36 ± 15 33 ± 13 58 ± 14 <0.001
SVI mL/m2 31 ± 10 30 ± 10 43 ± 20 <0.001
RVEDVI mL/m2 92 ± 26 94 ± 28 74 ± 25 0.004
RVESVI mL/m2 61 ± 27 64 ± 28 31 ± 16 <0.001
RVMI g/m2 52 ± 19 53 ± 18 36 ± 16 <0.001
6MWD m 305 ± 117(77) 404 ± 116(21) 0.001
NTproBNP pg/mL 1140 (96 –
3577)(75)
182 (45 – 243)
(12)
<0.001

Data presented as % (n), mean±sd or median (IQR) unless otherwise stated.

*

p value comparison between controls and subgroup 84 PAH patients.

PAH: pulmonary arterial hypertension; RV: right ventricle; IPAH: idiopathic PAH; FPAP: familial PAH; CTDPH: connective tissue disease associated PH; POPH: portopulmonary hypertension; CHD: congenital heart disease associated PH; PDE5i: phosphodiesterase type 5 inhibitor; ERA: endothelial receptor antagonist; CCB: calcium channel blocker; mPAP: mean pulmonary artery pressure; RAP: right atrial pressure; PVR: pulmonary vascular resistance; CI: cardiac index; SV/PP: compliance, ratio stroke volume/pulse pressure; RVEF: RV ejection fraction; SVI: stroke volume index; RVEDVI: RV end diastolic volume index; RVESVI: RV end systolic volume index; RVMI: RV mass index; 6MWD: six minute walk distance; NTproBNP: N terminal pro-brain natriuretic peptide.