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. Author manuscript; available in PMC: 2016 Aug 26.
Published in final edited form as: Hypertension. 2013 Jan 2;61(3):690–700. doi: 10.1161/HYPERTENSIONAHA.111.00318

Figure 3.

Figure 3

Recombinant human NEP produces Ang(2-7) and Ang(5-10) from Ang(2-10). Ang(2-10) label is inside a text box to indicate that it was the added substrate. Peak areas were normalized to total angiotensin peptide current and bars show mean of three experiments and one standard deviation about the mean. Ang(2-10) with recombinant human NEP alone, or pretreated with 1 μmol/L SCH39370 (NEP inhibitor) or 70 nmol/L thiorphan (NEP inhibitor) was sampled at 15 minutes. Production of both Ang(2-7) and Ang(5-10) was decreased in the presence of the NEP inhibitors.