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. Author manuscript; available in PMC: 2017 Aug 25.
Published in final edited form as: J Med Chem. 2016 Aug 10;59(16):7634–7650. doi: 10.1021/acs.jmedchem.6b00860

Figure 5.

Figure 5

Effects of compound 19 on oxycodone-induced conditioned place preference. Oxycodone (3 mg/kg, i.p.) conditioning in the (Vehicle + oxycodone) produced a robust place preference to the oxycodone-paired compartment. Pretreatment with 19 (5, 15 mg/kg, i.p., 15 min before oxycodone injection) dose-dependently blocked the acquisition of oxycodone-induced CPP. Compound 19 alone (15 mg/kg, i.p.) in the (19 + saline) group did not produce significant place preference. ** p<0.01, compared to the (Vehicle + vehicle) group; ## p<0.01, compared to the (Vehicle + oxycodone) group. The number on each bar shows the animal number in each experimental group.