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. Author manuscript; available in PMC: 2017 Aug 25.
Published in final edited form as: J Med Chem. 2016 Aug 10;59(16):7634–7650. doi: 10.1021/acs.jmedchem.6b00860

Scheme 2. Synthesis of 35a.

Scheme 2

aReagents and conditions: (a) 11b, K2CO3, acetone, reflux, overnight; (b) hydrazine, EtOH, reflux, overnight; (c) 4-methyl-1H-imidazole-2-carboxylic acid, CDI, THF, 0 °C to room temperature, overnight.