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Insulin secretion declines with age in human islets. Insulin secretion (2 mmol/L glucose [2G] and 17 mmol/L glucose [17G]) (A), stimulation index (SI) (i.e., stimulated/basal secretion) (B), insulin content (C), and BMI (D) are shown as a function of donor age (n = 31). E and F: Insulin secretion (17G) and SI as a function of BMI (n = 31). Donor information is listed in Supplementary Table 1.
