Table 1.
Serum metabolites, hormones, and lipids in WT and AdSod2 KO mice fed NCD or HFD
| NCD |
HFD |
|||
|---|---|---|---|---|
| WT | AdSod2 KO | WT | AdSod2 KO | |
| Glucose (mg/dL) | 109.9 ± 8.1 | 99.3 ± 10.8 | 146 ± 6.3## | 129.8 ± 5.9# |
| T0 insulin (ng/mL) | 0.34 ± 0.06 | 0.3 ± 0.06 | 0.54 ± 0.06 | 0.21 ± 0.03** |
| T30 insulin (ng/mL) | 0.48 ± 0.09 | 0.47 ± 0.1 | 0.47 ± 0.08 | 0.35 ± 0.05 |
| Leptin (ng/mL) | 5 ± 0.5 | 5.4 ± 0.8 | 14.6 ± 4.3 | 4.1 ± 0.9* |
| Adiponectin (ng/mL) | 7,443.1 ± 505.1 | 7,242.1 ± 504.8 | 6,890 ± 413.8 | 7,183 ± 579.6 |
| FFA (mmol/L) | 0.46 ± 0.03 | 0.63 ± 0.07 | 0.46 ± 0.06 | 0.28 ± 0.03* |
| Triglycerides (mg/dL) | 104.1 ± 8.1 | 92.2 ± 10.6 | 74.9 ± 16.8 | 63.3 ± 16.1 |
| Cholesterol (mg/dL) | 236.9 ± 27.7 | 230.7 ± 10.8 | 195.8 ± 31.6 | 236.8 ± 19.1 |
Data are mean ± SEM. Serum metabolites, hormones, and lipids were measured after a 6-h fast. T0 insulin and T30 insulin correspond to insulin measured before glucose injection and 30 min after glucose injection, respectively, during GTTs. All other metabolites and hormones were determined by blood samples extracted before glucose injection before GTTs. n = 5 mice per genotype for NCD and n = 8 mice per genotype for HFD.
*P < 0.05 vs. WT mice under the same feeding condition.
**P < 0.005 vs. WT mice under the same feeding condition.
#P < 0.05 vs. NCD within the same genotype.
##P < 0.005 vs. NCD within the same genotype.