Figure 2.

Comparison of hepatic uptake of [¹¹C]5-HTP between nontransplanted subjects with T1D (A) and subjects with IPX with good function (B) and low function (C). The renal [¹¹C]5-HTP uptake is absent in B due to renal failure (subject IPX2 was transplanted with islets after receiving a kidney transplant). The renal uptake, although high in comparison, does not affect the liver measurement due to spillover effects. The average hepatic background uptake was SUV = 1.68 in nontransplanted subjects, which was lower than the average SUV = 2.14 in subjects with a hepatic islet graft (D). K, kidney; L, liver; P, pancreas.