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. 2016 Aug 18;17(Suppl 4):543. doi: 10.1186/s12864-016-2792-1

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The EpiTracer workflow. a Gene expression profiles of each condition are mapped onto the base PPI network. b Highest activity paths are calculated for each condition, and common paths are discarded, giving condition-specific highest activity paths (CSHAPs). c The network induced by the CSHAPs form the condition-specific highest activity networks (CSHANs). d Nodes in the perturbed highest activity network are ranked according to ripple centrality. e The ranked list of nodes is split into two lists based on overlaps with the control highest activity network. Top 10 nodes in the list unique to the perturbed condition form the epicenters specific to the perturbation