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. 2016 Aug 18;17(Suppl 4):543. doi: 10.1186/s12864-016-2792-1

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Case study 1 (PARK2 overexpression in human glioma cell line). Data corresponding to overexpression of PARK2 in human glioma cell line (U251). a Human PPI network comprising of 10,306 nodes and 74,404 edges. Nodes colored red are upregulated upon perturbation, and nodes colored green are downregulated. (a1) Table of network properties. b Perturbation-specific *HAN (highest activity network), with network properties in table b1. c The 5 epicenters which were differentially expressed, along with their immediate neighbors d List of epicenters specific to the perturbation as well as global epicenters