Figure 1.

Amphetamine increases aerobic capacity at room temperature. Amphetamine at a higher dose (2mg/kg) increased VO_2Max (A) and time to achieve VO_2MAX (B), while Amp at a lower dose 1 mg/kg) increased only time to VO_2Max (B). Rats received (i.p.) either saline or one of 2 doses of Amp; 5 min later they performed the incremental treadmill test at 24°C for assessment of VO_2Max. Metabolic measurements were obtained via an indirect open-circuit calorimetric system with analysis of gases collected from an enclosed motorized treadmill chamber (Oxymax). In a crossover design, at least 2 d later, the animal groups were reversed and the trial repeated. Horizontal bars represent trial means ± SEM. n = 6 per group.