TABLE 3.
Altered cellular morphology and function pathways in embryonic cardiomyocytes after DNMT3a siRNA treatment
| Pathway |
P |
Molecules (n) |
|---|---|---|
| Cell death and survival | ||
| Proliferation of cells | 1.14E-18 | 379 |
| Cell death | 8.18E-18 | 347 |
| Apoptosis | 2.12E-17 | 288 |
| Necrosis | 2.13E-17 | 282 |
| Cell death of cardiomyocytes | 4.87E-08 | 34 |
| Cell morphology, cellular assembly, and organization | ||
| Morphology of cells | 2.34E-21 | 240 |
| Differentiation of cells | 2.60E-19 | 261 |
| Organization of cytoskeleton | 1.59E-16 | 175 |
| Organization of filaments | 2.10E-11 | 39 |
| Formation of myofilaments | 9.52E-10 | 9 |
| Size of cells | 1.12E-09 | 61 |
| Organization of organelle | 8.39E-09 | 70 |
| Organization of actin cytoskeleton | 9.99E-09 | 45 |
| Organization of actin filaments | 4.62E-08 | 21 |
| Morphology of sarcomere | 6.96E-07 | 9 |
| Formation of cytoskeleton | 9.91E-07 | 48 |
| Cell signaling | ||
| Quantity of Ca2+ | 1.30E-11 | 63 |
| Homeostasis of Ca2+ | 1.54E-09 | 26 |
| Release of Ca2+ | 2.28E-07 | 32 |
| Concentration of cyclic AMP | 9.44E-07 | 29 |