TABLE 7.
Methylation changes in promoter CpGs after knockdown of DNMT3a expression for 72 h
| Gene | CpG location in amplicona | FDR of methylation change | Methylation difference (%) | Fold change in gene expressionb | FDR of fold change |
|---|---|---|---|---|---|
| Myh7_1 | 102 (2) | 0 | −6.20 | 1.99 | 0.015563 |
| Myh7_1 | 118 (3) | 0 | −6.64 | ||
| Myh7_1 | 127 (4) | 0 | −9.72 | ||
| Myh7_1 | 234 (6) | 0 | −5.05 | ||
| Myh7b_1 | 161 (3) | 0 | −5.79 | 3.19 | 0.00021 |
| Myh7b_2 | 352 (4) | 0 | −7.86 | ||
| Tnni3_1 | 244 (5) | 0 | −5.64 | 3.44 | 6.15E-15 |
| Tnni3_1 | 355 (6) | 0 | −5.07 | ||
| Tnnt2_1 | 94 (1) | 0 | −6.96 | 1.64 | 0.000163 |
| Tnnt2_1 | 195 (3) | 0 | −9.75 | ||
| Tnnt2_2 | 58 (1) | 0 | −5.58 | ||
| Tnnt2_2 | 209 (3) | 0 | −6.72 | ||
| Tnnt2_2 | 224 (4) | 0 | −6.00 | ||
| Tnnt2_2 | 233 (5) | 0 | −7.83 | ||
| Nppa_1 | 77 (2) | 0 | 5.978 | 4.25 | 1.39E-24 |
| Nppb_2 | 328 (4) | 0 | 11.20 | 7.64 | 6.30E-52 |
| Nppb_2 | 341 (5) | 0 | 11.71 | ||
| Nppb_2 | 381 (6) | 0 | 10.21 | ||
| Mef2c_1 | 348 (6) | 2.43E-05 | −6.30 | — | — |
| Mef2d_1 | 26 (1) | 0.000177 | −11.27 | — | — |
| Mef2d_2 | 304 (7) | 0 | −6.02 | ||
| Cdkn1C_1 | 26 (2) | 0.000329 | −6.55 | — | — |
| Cdkn1C_1 | 40 (4) | 6.85E-06 | −6.55 | ||
| Cdkn1C_1 | 66 (8) | 3.68E-06 | −5.35 | ||
| Cdkn1C_1 | 69 (9) | 5.18E-05 | −5.63 | ||
| Cdkn1C_1 | 104 (11) | 6.05E-08 | −7.27 | ||
| Cdkn1C_1 | 265 (36) | 0 | −5.93 | ||
| Cdkn1C_1 | 287 (40) | 0 | −5.56 | ||
| Cdkn1C_1 | 291 (41) | 0 | −5.83 | ||
| Cdkn1C_1 | 340 (48) | 9.23E-07 | −5.20 |
a
Numbers in parentheses indicate the order of CpG site within the amplicon.
b
Values from RNA-Seq analysis.