TABLE 8.

Methylation changes in promoter CpGs after knockdown of DNMT3b expression for 72 h

Gene	CpG location in amplicona	FDR of methylation change	Methylation difference (%)	Fold change in gene expressionb	FDR of fold change
Myh6_1	43 (1)	0	−5.12	2.68	1.45E-16
Myh7b_1	145 (2)	0	−41.27	2.01	0.039445
Myh7b_1	161 (3)	0	−12.51
Tnni3_1	66 (1)	0	−5.48	4.15	4.87E-25
Tnni3_1	194 (4)	0	−5.32
Tnni3_1	355 (6)	0	−6.71
Tnnt2_1	195 (3)	0	−6.89	1.98	6.72E-11
Tnnt2_1	201 (4)	0	−5.42
Tnnt2_1	350 (5)	0	−5.35
Tnnt2_1	420 (6)	9.28E-14	−5.52
Tnnt2_2	224 (4)	0	−5.53
Tnnt2_2	233 (5)	0	−5.47
Nppa_1	125 (3)	0	−7.13	4.76	4.04E-36
Nppa_1	133 (4)	0	−6.85
Nppa_1	296 (6)	0	−7.27
Nppa_1	303 (7)	0	−7.62
Nppa_1	310 (8)	0	−7.40
Nppa_1	352 (9)	0	−7.53
Nppb_2	328 (4)	0	−8.12	3.62	4.17E-19
Nppb_2	341 (5)	0	−9.99
Nppb_2	381 (6)	1.29E-08	−5.84
Mef2d_1	26 (1)	0.033702	−6.91	—	—
Cdkn1A_1	374 (4)	0	13.00	—	—
Cdkn1C_1	24 (1)	5.11E-05	−9.39	1.81	0.000374
Cdkn1C_1	26 (2)	2.19E-05	−7.52
Cdkn1C_1	33 (3)	0.000303	−6.04
Cdkn1C_1	40 (4)	1.10E-13	−10.41
Cdkn1C_1	54 (5)	2.27E-08	−6.65
Cdkn1C_1	60 (7)	5.78E-10	−8.07
Cdkn1C_1	66 (8)	9.62E-07	−5.42
Cdkn1C_1	69 (9)	3.42E-10	−8.45
Cdkn1C_1	96 (10)	2.52E-07	−6.39
Cdkn1C_1	104 (11)	2.15E-07	−6.64
Cdkn1C_1	106 (12)	7.63E-10	−7.55
Cdkn1C_1	115 (16)	2.61E-06	−5.66
Cdkn1C_1	123 (18)	4.22E-10	−7.73
Cdkn1C_1	131 (19)	1.32E-06	−5.39
Cdkn1C_1	203 (27)	0	-5.48
Cdkn1C_1	209 (28)	0	−6.69
Cdkn1C_1	213 (29)	0	−7.78
Cdkn1C_1	237 (31)	0	−5.15
Cdkn1C_1	258 (34)	0	−5.43
Cdkn1C_1	262 (35)	0	−5.47
Cdkn1C_1	265 (36)	0	−10.30
Cdkn1C_1	269 (37)	0	−10.10
Cdkn1C_1	273 (38)	0	−8.45
Cdkn1C_1	283 (39)	0	−7.51
Cdkn1C_1	287 (40)	0	−11.05
Cdkn1C_1	291 (41)	0	−11.00
Cdkn1C_1	298 (42)	0	−6.08
Cdkn1C_1	307 (44)	0	−8.74
Cdkn1C_1	313 (45)	0	−9.62
Cdkn1C_1	327 (47)	0	−6.15

^aNumbers in parentheses indicate the order of CpG site within the amplicon.

^bValues from RNA-Seq analysis.