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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Immunol. 2016 Jul 29;197(5):1823–1831. doi: 10.4049/jimmunol.1600717

Fig. 4. VEGF-A and the corresponding receptor VEGFR-2 are expressed at increased levels at the site of L. major infection.

Fig. 4

C57BL/6 mice were infected with L. major parasites in the ear dermis and ears were analyzed by qRT-PCR at 5, 9 and 15 wks p.i. for the expression of VEGF-A (A), VEGFR-2 (B), VEGF-C (C), VEGF-D (D), and VEGFR-3 (E). F: qRT-PCR for VEGF-A expression in LNs draining infected and naïve control ears at 5 wk p.i. G and H: qRT-PCR for HIF1α expression at 5 wk p.i. in naïve and infected ears (G) and dLNs (H). Relative mRNA expression normalized to the housekeeping RPS11 gene is presented as the mean +SEM with 5 mice per group. Data are representative of at least 2 independent experiments. ***P < 0.0005, **P < 0.005, *P < 0.05, t-test comparing infected mice to controls.