Table 3 Demographic data and clinical data of the study cohort of the cross-sectional study group (B; n = 67). Data are presented as means and 95 % confidence intervals, or frequencies and percentages. A p-value < 0.05 indicated group significance.
| CTRL | PE | IUGR | HELLP | ICP | p-value | ||
|---|---|---|---|---|---|---|---|
| n = 31 | n = 13 | n = 10 | n = 6 | n = 7 | |||
| Maternal age (years) | Mean | 31.25 | 31.22 | 30.65 | 37.12 | 31.74 | 0.2739 |
| lower 95 % CI of mean | 29.16 | 27.73 | 26.52 | 31.39 | 25.83 | ||
| upper 95 % CI of mean | 33.35 | 34.72 | 34.78 | 42.84 | 37.65 | ||
| Maternal pre-pregnancy BMI (kg/m2) | Mean | 22.72 | 25.18 | 22.03 | 22.76 | 23.59 | 0.1925 |
| lower 95 % CI of mean | 21.6 | 23.18 | 19.58 | 18.99 | 19.83 | ||
| upper 95 % CI of mean | 23.83 | 27.17 | 24.48 | 26.53 | 27.34 | ||
| Assisted reproductive technologies (ART) | % | 3.2 | 7.7 | 10.0 | 0.0 | 14.2 | 0.7326 |
| n | 1 | 1 | 1 | 0 | 1 | ||
| Primiparity | % | 54.84 | 53.85 | 70.00 | 66.67 | 71.43 | 0.8351 |
| n | 17 | 7 | 7 | 4 | 3 | ||
| Systolic blood pressure (mmHg) | mean | 114.8 | 149.8 | 121.2 | 156.5 | 120.1 | < 0.0001 |
| lower 95 % CI of mean | 110.4 | 144.5 | 106 | 131.4 | 109.4 | ||
| upper 95 % CI of mean | 119.3 | 155.2 | 136.4 | 181.6 | 130.9 | ||
| Diastolic blood pressure (mmHg) | mean | 68 | 91.38 | 69.6 | 91.5 | 71 | < 0.0001 |
| lower 95 % CI of mean | 64.63 | 86.23 | 60.14 | 82.14 | 64.08 | ||
| upper 95 % CI of mean | 71.37 | 96.54 | 79.06 | 100.9 | 77.92 | ||
| Weeks of gestation at sampling | mean | 33.27 | 33.87 | 32.17 | 32.38 | 35.06 | 0.8420 |
| lower 95 % CI of mean | 31.4 | 30.8 | 27.46 | 27.53 | 31.59 | ||
| upper 95 % CI of mean | 35.14 | 36.94 | 36.89 | 37.23 | 38.54 | ||
| Weeks of gestation at delivery | mean | 39.28 | 34.68 | 32.44 | 32.38 | 37.67 | < 0.0001 |
| lower 95 % CI of mean | 38.84 | 31.78 | 27.81 | 27.53 | 36.55 | ||
| upper 95 % CI of mean | 39.71 | 37.58 | 37.08 | 37.23 | 38.79 | ||
| Mode of delivery (c-section) | % | 45.16 | 84.62 | 90.00 | 100.00 | 42.86 | 0.0050 |
| n | 14 | 11 | 9 | 6 | 3 | ||
| Neonatal gender (female) | % | 54.8 | 38.5 | 50.0 | 83.3 | 100.0 | 0.0589 |
| N | 17 | 5 | 5 | 5 | 7 | ||
| Neonatal birth weight (g) | mean | 3 424 | 2 242 | 1 344 | 1 818 | 3 123 | < 0.0001 |
| lower 95 % CI of mean | 3 289 | 1 649 | 650.8 | 908.9 | 2 715 | ||
| upper 95 % CI of mean | 3 559 | 2 834 | 2 036 | 2 726 | 3 530 | ||
| Neonatal birth weight percentiles | mean | 52.3 | 29.3 | 2.1 | 31.6 | 49.0 | < 0.0001 |
| lower 95 % CI of mean | 43.6 | 16.2 | 1.0 | 5.7 | 19.1 | ||
| upper 95 % CI of mean | 61.0 | 42.3 | 3.2 | 57.5 | 78.9 | ||
| Proteinuria (mg/24 h) | mean | N/A | 2 964 | N/A | N/A | N/A | |
| lower 95 % CI of mean | N/A | 357 | N/A | N/A | N/A | ||
| upper 95 % CI of mean | N/A | 5 572 | N/A | N/A | N/A | ||
| AST (U/L) | mean | 23.0 | 27.4 | 22.5 | 437.3 | 172.7 | < 0.0001 |
| lower 95 % CI of mean | 20.6 | 22.4 | 20.0 | 156.5 | 83.4 | ||
| upper 95 % CI of mean | 25.3 | 32.4 | 25.0 | 718.2 | 262.1 | ||
| ALT (U/L) | mean | 13.7 | 18.7 | 13.9 | 402.8 | 283.6 | < 0.0001 |
| lower 95 % CI of mean | 11.8 | 13.1 | 10.6 | 194.9 | 115.9 | ||
| upper 95 % CI of mean | 15.5 | 24.3 | 17.2 | 610.7 | 451.2 | ||
| Platelets (G/L) | mean | 264.9 | 217.3 | 238.5 | 45.8 | 267.6 | 0.0002 |
| lower 95 % CI of mean | 242.8 | 175.7 | 200.9 | 18.4 | 156.5 | ||
| upper 95 % CI of mean | 287.0 | 258.9 | 276.1 | 73.2 | 378.7 | ||
| Haptoglobin (mg/mL) | mean | N/A | N/A | N/A | 8.4 | 101.0 | |
| lower 95 % CI of mean | N/A | N/A | N/A | − 2.5 | 48.9 | ||
| upper 95 % CI of mean | N/A | N/A | N/A | 19.3 | 153.1 | ||
| Bile acids (µmol/L) | mean | N/A | N/A | N/A | N/A | 30.17 | |
| lower 95 % CI of mean | N/A | N/A | N/A | N/A | 20.61 | ||
| upper 95 % CI of mean | N/A | N/A | N/A | N/A | 39.73 | ||