Table 4 Lipid profiles and progesterone and estrogen metabolome in the cross-sectional study arm (B; n = 67). Data are presented as median and 95 % confidence intervals. Significant differences in concentrations between the respective study group vs. the CTRL group are indicated as follows: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. a) PE vs. CTRL, b) IUGR vs. CTRL, c) HELLP vs. CTRL, d) ICP vs. CTRL.
| Name | Chemical name | Units | CTRL | PE a) | IUGR b) | HELLP c) | ICP d) | p-value | |
|---|---|---|---|---|---|---|---|---|---|
| Lipid profile | |||||||||
| LDL cholesterol | mg/dL | median | 136 | 152 | 103.5 | 109.5 | 188 | b)* | |
| lower 95 % CI | 128 | 93 | 67 | 61 | 141 | ||||
| upper 95 % CI | 162 | 193 | 141 | 148 | 335 | ||||
| HDL cholesterol | mg/dL | median | 79 | 64 | 81 | 68 | 57 | d)** | |
| lower 95 % CI | 71 | 45 | 56 | 40 | 48 | ||||
| upper 95 % CI | 84 | 86 | 107 | 128 | 62 | ||||
| Total cholesterol | mg/dL | median | 264 | 260 | 231 | 206.5 | 299 | a)* | |
| lower 95 % CI | 247 | 203 | 188 | 182 | 221 | b)* | |||
| upper 95 % CI | 276 | 331 | 251 | 249 | 454 | ||||
| Triglycerides | mg/dL | median | 219 | 304 | 174 | 247 | 261 | ||
| lower 95 % CI | 168 | 178 | 121 | 88 | 170 | ||||
| upper 95 % CI | 267 | 444 | 256 | 643 | 345 | ||||
| Basic steroid hormone profile | |||||||||
| Progesterone | pregn-4-ene-3,20-dione | ng/mL | median | 98.1 | 98.16 | 51.32 | 110.6 | 105.7 | b)** |
| lower 95 % CI | 75.58 | 81.74 | 37.99 | 43.22 | 72.37 | ||||
| upper 95 % CI | 109.9 | 125.4 | 78.65 | 180.3 | 134.8 | ||||
| Estradiol (E2) | 17β-estradiol | ng/mL | median | 21.57 | 21.4 | 17.59 | 21.59 | 31.36 | b)* |
| lower 95 % CI | 19.12 | 16.77 | 12.48 | 10.43 | 21.28 | ||||
| upper 95 % CI | 27.85 | 24.86 | 22.08 | 28.04 | 34.26 | ||||
| DHEA | 5-androsten-3β-ol-17-one | ng/mL | median | 20.24 | 24.47 | 22.69 | 17.95 | 17.56 | |
| lower 95 % CI | 13.72 | 17.11 | 6.12 | 11.54 | 11.49 | ||||
| upper 95 % CI | 24.3 | 41.75 | 38.19 | 28.96 | 24.53 | ||||
| Extended metabolome profile | |||||||||
| 6β-hydroxy-progesterone | 4-pregnen-6β-ol-3,20-dione | ng/mL | median | 9.1 | 9.9 | 9.8 | 10.0 | 10.4 | |
| lower 95 % CI | 8.1 | 7.0 | 8.6 | 7.9 | 8.2 | ||||
| upper 95 % CI | 10.4 | 15.0 | 11.8 | 18.4 | 11.6 | ||||
| 5β-dihydro-progesterone | 5β-pregnan-3,20-dione | ng/mL | median | 16.2 | 19.1 | 17.5 | 17.3 | 15.5 | |
| lower 95 % CI | 14.2 | 15.6 | 12.7 | 10.6 | 11.8 | ||||
| upper 95 % CI | 18.7 | 27.2 | 23.3 | 23.5 | 24.4 | ||||
| 5α-dihydro-progesterone | 5α-pregnan-3,20-dione | ng/mL | median | 105.9 | 129.1 | 84.8 | 137.7 | 114.3 | |
| lower 95 % CI | 93.7 | 121.1 | 58.2 | 86.4 | 47.7 | ||||
| upper 95 % CI | 133.2 | 180.4 | 151.7 | 730.0 | 173.4 | ||||
| 3α,5α-tetrahydro-progesterone allopregnanolone | 5α-pregnan-3α-ol-20-one | ng/mL | median | 15.7 | 13.6 | 8.1 | 16.2 | 13.9 | b)** |
| lower 95 % CI | 11.6 | 11.3 | 6.6 | 8.8 | 9.5 | ||||
| upper 95 % CI | 16.6 | 15.4 | 13.7 | 32.5 | 21.6 | ||||
| 20α-dihydro-3β,5α-tetrahydro-progesterone | 5α-pregnan-3β,20α-diol | ng/mL | median | 6.9 | 7.4 | 5.6 | 7.9 | 8.2 | |
| lower 95 % CI | 6.0 | 5.6 | 2.4 | 4.8 | 6.1 | ||||
| upper 95 % CI | 7.5 | 11.2 | 8.4 | 18.9 | 16.6 | ||||
| 17-hydroxy-progesterone | 4-pregnen-17α-ol-3,20-dione | ng/mL | median | 21.1 | 24.6 | 22.5 | 20.5 | 23.3 | |
| lower 95 % CI | 20.0 | 19.7 | 16.9 | 16.0 | 20.8 | ||||
| upper 95 % CI | 23.4 | 28.2 | 26.0 | 30.6 | 29.5 | ||||
| 17α,20α-dihydro-progesterone | 4-pregnen-17,20α-diol-3-one | ng/mL | median | 38.0 | 42.4 | 39.7 | 47.9 | 40.6 | |
| lower 95 % CI | 35.3 | 35.0 | 29.1 | 24.2 | 14.5 | ||||
| upper 95 % CI | 44.8 | 55.7 | 54.2 | 54.0 | 52.6 | ||||
| 11-keto-progesterone | 4-pregnen-3,11,20-trione | ng/mL | median | 67.5 | 79.3 | 64.1 | 64.8 | 70.0 | a)* |
| lower 95 % CI | 65.5 | 71.0 | 45.5 | 54.5 | 63.4 | ||||
| upper 95 % CI | 73.4 | 103.2 | 74.1 | 112.9 | 89.6 | ||||
| Estriol (E3) | 1,3,5(10)-estratrien-3,16α,17β-triol | ng/mL | median | 12.2 | 12.9 | 10.6 | 12.4 | 15.2 | b)* |
| lower 95 % CI | 11.3 | 10.5 | 8.0 | 5.8 | 9.9 | ||||
| upper 95 % CI | 13.3 | 14.1 | 11.8 | 18.5 | 16.4 | ||||