Figure 3.
Oligonucleotide delivery strategies. Several approaches to oligonucleotide delivery are depicted. (A) Antibody-oligonucleotide conjugate. (B) Polymer-oligonucleotide conjugate with PEGylation and targeting ligand. (C) Molecular scale ligand-oligonucleotide conjugate with triantennary carbohydrate ligand. (D) Lipid nanoparticle with PEGylation. (E) Gold nanoparticle with dense oligonucleotide coat. (F) DNA nanostructure with oligonucleotide and targeting ligand incorporated. Images are not to scale.