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. 2016 Apr 15;44(14):6676–6692. doi: 10.1093/nar/gkw252

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Cohesive sites overlap highly transcribed RNAPII regions. (A) Pie-chart showing overlap between Mis4+/Rad21+ loci and RNAPII genes, with a mere 4% overlap with only RNAPIII genes. (B) Pie-chart showing overlap between Rad21+ loci and RNAPII and RNAPIII genes. (C) Histogram showing the distribution of RNAPII genes versus gene expression in non-cohesin associated genes (blue bars, 1412 genes), cohesive (red bars, 91 genes) and non-cohesive loci (green bars, 187 genes). (D) Boxplots showing expression levels (Reads per Kilobase per Million; RPKM) of genes that overlap with Mis4+/Rad21+ and Rad21+ sites. P < 10⁻⁹, Wilcoxon Rank Sum test. (E) Boxplots showing expression level (reads per kilobase per million; RPKM) of genes that overlap with Ssl3+/Rad21+ and Rad21+ sites. P < 10⁻⁷, Wilcoxon Rank Sum test. (F) Graph showing Swi6 occupancy at Mis4+/Rad21+ and Rad21+ loci. (G) Boxplots showing Mis4+/Rad21+ sites overlap with highly expressed genes in comparison to Rad21+ sites, including or excluding Swi6 loci. Changes in gene expression of Mis4+/Rad21+/Swi6− loci compared to Mis4+/Rad21+/Swi6+ loci and Rad21+/Swi6− loci compared to Rad21+/Swi6+ loci are not significant. Changes in gene expression of Mis4+/Rad21+/Swi6− loci compared to Rad21+/Swi6− loci and Mis4+/Rad21+/Swi6+ loci compared to Rad21+/Swi6+ loci are significant (P < 10⁻⁹, Wilcoxon Rank Sum test).