Figure 6.

Correlation between the selectivity of different INSTIs for ST over 3′-P and the change in susceptibility induced by the SH resistance mutant. The selectivity index was calculated as the IC₅₀ for 3′-P for each compound divided by the corresponding IC₅₀ for ST in the context of WT IN. Change in susceptibility was calculated as the IC₅₀ for ST for each compound in the context of the SH mutant divided by the corresponding IC₅₀ in the context of WT IN. Linear regression and statistical analyses including P-values and Pearson correlation (r) are indicated.