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. 2016 Jul 4;44(14):6625–6638. doi: 10.1093/nar/gkw600

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Relief of TI is modulated by the intrinsic properties of the repressors. Relief of TI is plotted as P_RE versus P_R activity (in the absence of CII). Data on relief of TI by CI is from Figure 3C and D, and dCas9 from Figure 5C and D. Relief of TI at P_RE by Cro repression of P_R was measured with Cro expressed either from the chromosomal LacZ reporter itself (1xcro) or from the reporter and additionally from a second chromosomal P_R.cro expression construct (2xcro) (see main text for details). Vertical and horizontal error bars are 95% confidence intervals in P_RE and P_R activity, respectively (n = 9 for CI and dCas9, n = 6 for Cro). Cyan shaded region shows simulated P_RE activity at different magnitude of P_R repressions for fast kinetics repressors of P_R, k_U = 0.5 s^–1 with either strong or weak barrier parameters (Figure 2).