Figure 6.

PTC readthrough in different human cancer cell lines with homozygous nonsense mutations at different positions in the TP53 gene. The cell lines (mutations shown in parentheses), were exposed for 96 h to CDX5-1 and G418, alone or in combination, and full-length p53 (red arrowhead) and truncated p53 (black arrowhead) was quantified relative to truncated p53 found in untreated cells, or to truncated p53 found in treated cells if no p53 signal was detected in untreated cells. The +4 nucleotide is indicated for each codon.