Fig 7. Lower maximal activities of 2-oxoglutarate dehydrogenase (OGDH) in hSOD1^G93A gastrocnemius muscle.

The maximal activities of OGDH in extracts from gastrocnemius muscle of male wild-type and hSOD1^G93A mice at different disease stages are compared. Stages are defined as presymptomatic (days 35–36), onset (days 63–75), mid-stage (days 110–130) and end-stage (days 150–175). The inset above the graph shows the two-way ANOVA p-values for the effects of genotype and disease stage, indicating that 2-oxoglutarate activity in hSOD1^G93A mice declines with progression of disease. The star denotes significance in the Bonferroni post test (* p<0.05).