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. 2016 Aug 26;12(8):e1006276. doi: 10.1371/journal.pgen.1006276

Fig 1. The C. elegans cnnm family.

Fig 1

(A) Phylogenetic tree of CNNM family. Amino acid sequences of C. elegans CNNMs, along with human, mouse, frog, zebrafish, and fruit fly CNNM orthologues, were aligned using Clustal W (version 2.1, http://clustalw.ddbj.nig.ac.jp/), and the phylogenetic tree was generated with neighbor-joining method by using Clustal W2—phylogeny (http://www.ebi.ac.uk/Tools/phylogeny/clustalw2_phylogeny/). Vertebrate CNNM orthologues are grouped, and C. elegans CNNMs are also grouped. Bar, 0.1 substitutions per amino acid. (B) Schematic illustrations of the cnnm family genes. Exons and introns are indicated by boxes and lines, respectively. The regions encoding the evolutionarily conserved DUF21 and CBS domains are indicated with black and gray boxes, respectively. Sequence names are shown in parentheses. The illustrations were generated using the Exon-Intron Graphic Maker by Nikhil Bhatla (http://www.wormweb.org/exonintron). Lines, deletion; arrowhead, point mutation; arrow, Mos1 insertion. Bar, 0.5 kb.