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. 2016 Mar 18;107(5):601–608. doi: 10.1111/cas.12907

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(a) Effect of mesenchymal stem cells on tumor stromal reaction. Expression of α‐smooth muscle actin (α‐SMA) and collagen I was higher in mixed‐cell tumors than in KM12SM tumors. (b) Effect of regorafenib on tumor growth and lymph node metastasis in orthotopic colon tumor models. Regorafenib inhibited the growth of both KM12SM and mixed‐cell tumors. Average tumor volume of mice not treated with regorafenib was set as 100% for both the tumor types. The rate of tumor reduction after regorafenib treatment was significantly higher (78% vs 45%; P < 0.05) in mixed‐cell tumors than in KM12SM tumors. Data are expressed as mean ± SE; *P < 0.05.