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. 2016 Aug 26;12(8):e1005085. doi: 10.1371/journal.pcbi.1005085

Fig 4. Subnetwork analysis for P. putida.

Fig 4

(a) Example error of ‘naïve’ iGSM merging where the initial P. putida BCM contains a biologically inaccurate carbon dioxide fixation cycle due to incorrect directionalities in the IGSMs. This error is automatically resolved as COMMGEN assigns reaction directionalities opposite to those shown with dashed reaction arrows. (b) Example for a new metabolic function in the consensus model. P. putida can grow on L-quinate as its sole carbon source. Neither of the initial models captures this behavior, whereas the consensus model provides the necessary, complementary reactions.