Figure 3.

CUR increases ATO-induced apoptosis by upregulating cleaved caspase-3 followed by PARP degradation in SKM-1 and KG1a cells. SKM-1 and KG1a cells were exposed to concentrations of CUR (10 μM) or ATO (8 μM) alone or CUR + ATO for 48 h and analyzed by (A) flow cytometry and (B) western blot analysis. Western blot analysis revealed cleaved caspase-3 and cleaved PARP fragment. (B) Representative data are shown. Data shown were from three independent experiments conducted in triplicate. The results are expressed as the means ± SD; ^**p<0.01, ^***p<0.001. The control groups were blank groups without treatment with CUR and ATO alone or in combination.