. 2016 Jul 15;36(3):1233–1242. doi: 10.3892/or.2016.4944

Table I.

Expression of apoptosis-related proteins in the treated groups.

Apoptosis-related proteins	SKM-1			KG1a
Apoptosis-related proteins	CUR/control (fold-change)	ATO/control (fold-change)	CUR+ATO/control (fold-change)	CUR/control (fold-change)	ATO/control (fold-change)	CUR+ATO/control (fold-change)
bad	1.141	1.741	2.044^a	1.224	0.951	0.854
bax	1.036	1.321	1.375	0.989	1.586	1.970^a
bcl-2	0.996	2.094	2.304^a	0.775	1.895	0.428^b
bcl-w	1.083	1.892	2.098^a	0.852	1.907	0.667^b
BID	0.739	0.272	0.543^b	0.934	1.254	1.138
BIM	1.146	2.071	2.389^a	0.883	0.962	0.843
caspase3	1.172	2.280	2.616^a	1.125	1.967	2.812^a
caspase8	1.118	2.952	3.118^a	1.157	1.075	1.152
CD40	0.930	1.534	1.634^a	0.789	0.870	0.771
CD40L	1.081	1.803	1.879^a	0.805	0.867	0.816
cIAP-2	0.934	0.491	0.528^b	0.664	1.320	0.345^b
cytoC	1.011	2.156	2.918^a	1.314	1.916	2.848^a
DR6	1.063	1.448	1.588^a	0.792	0.924	0.822
Fas	1.272	2.407	2.468^a	0.878	0.851	0.917
FasL	1.080	1.601	1.694^a	0.841	1.026	0.858
HSP27	0.894	1.424	1.297	0.881	1.112	0.905
HSP60	1.084	1.604	1.721^a	0.858	0.972	0.899
HSP70	1.350	2.763	2.968^a	1.244	1.059	1.171
HTRA	0.664	2.784	2.288^a	2.088	1.250	2.874^a
IGF-I	0.891	1.187	1.163	0.794	1.068	0.720
IGF-II	1.123	2.707	2.948^a	1.009	1.334	1.070
IGFBP-1	0.933	1.241	1.304	0.701	0.912	0.599^b
IGFBP-2	0.971	1.223	1.253	0.794	0.978	0.479^b
IGFBP-3	1.119	1.769	1.888^a	0.749	0.891	0.878
IGFBP-4	0.974	1.980	2.012^a	0.782	0.961	0.805
IGFBP-5	1.002	4.794	4.849^a	0.810	0.952	0.860
IGFBP-6	1.102	0.811	0.905	0.829	1.042	0.867
IGF-1sR	0.929	1.320	1.340	0.745	0.965	0.880
livin	1.139	43.971	47.444^a	0.913	1.102	0.910
p21	1.044	1.664	2.177^a	0.921	0.980	0.960
p27	1.200	2.269	2.624^a	0.918	1.057	0.950
p53	1.097	2.970	3.364^a	0.946	1.081	1.005
SMAC	1.025	0.979	1.069	1.032	1.062	1.523^a
Survivin	0.805	2.118	0.360^b	0.607	1.805	0.215^b
sTNF-R1	1.051	1.492	1.323	0.836	1.152	0.772
sTNF-R2	0.819	1.124	1.042	0.693	0.909	0.733
TNF-α	0.828	1.263	1.393	0.671	1.012	0.723
TNF-β	0.945	1.376	1.531^a	0.701	0.902	0.820
TRAILR-1	0.942	0.907	0.996	0.790	1.104	0.855
TRAILR-2	1.008	1.633	1.785^a	0.843	1.055	0.872
TRAILR-3	0.955	1.421	1.546^a	0.799	1.047	0.848
TRAILR-4	1.074	1.620	1.794^a	0.845	1.050	0.909
XIAP	0.896	1.340	0.550^b	0.741	1.155	0.403^b

SKM-1 and KG1a cells were treated with CUR (10 μM) and ATO (8 μM) alone or in combination for 48 h, followed by detection using a protein array kit. Fold-changes ≤0.667 or ≥1.5 indicated proteins were modulated by these drugs.

Upregulated,

downregulated.