. Author manuscript; available in PMC: 2017 Sep 1.

Published in final edited form as: Arthritis Rheumatol. 2016 Jul 29;68(9):2071–2082. doi: 10.1002/art.39745

Table I.

Neutrophil Subsets

Subset	Description	Functional Significance
N1	Tumor associated, hypersegmented neutrophils identified in association with factors in the tumor microenvironment	Pro-inflammatory neutrophil subset with antitumor cytotoxic effects.
N2	Tumor associated neutrophils seen in the majority of untreated tumors.	Anti-inflammatory neutrophil subset with tumorigenic effects.
OLFM4⁺	Found in 25% of human peripheral blood neutrophils within specific granules.	Unknown
CD177⁺	Present in the membrane of specific granules and the cell surface in 0–100% of neutrophils. The fraction of CD177⁺ neutrophils appears to be constant in each individual.	Binds to endothelial cell adhesion molecules and may facilitate migration across the endothelium. Predictor of relapse in ANCA-associated vasculitis.
CD16^dim/CD62L^bright	Immature, banded neutrophil identified in human experimental models of endotoxemia.	Reduced ability to opsonize bacteria and generate ROS.
CD16^bright/CD62L^dim	Hypersegmented neutrophil identified in human experimental models of endotoxemia.	Increased capacity to produce ROS and suppress T cell proliferation.
Low density granulocytes (LDGs)	Colocalize with mononuclear cells upon density gradient separation. Identified and characterized in various infectious and autoimmune diseases, notably systemic lupus erythematosus.	Pro-inflammatory neutrophil with enhanced propensity to form NETs