N1 |
Tumor associated, hypersegmented neutrophils identified in association with factors in the tumor microenvironment |
Pro-inflammatory neutrophil subset with antitumor cytotoxic effects. |
N2 |
Tumor associated neutrophils seen in the majority of untreated tumors. |
Anti-inflammatory neutrophil subset with tumorigenic effects. |
OLFM4+ |
Found in 25% of human peripheral blood neutrophils within specific granules. |
Unknown |
CD177+ |
Present in the membrane of specific granules and the cell surface in 0–100% of neutrophils. The fraction of CD177+ neutrophils appears to be constant in each individual. |
Binds to endothelial cell adhesion molecules and may facilitate migration across the endothelium. Predictor of relapse in ANCA-associated vasculitis. |
CD16dim/CD62Lbright |
Immature, banded neutrophil identified in human experimental models of endotoxemia. |
Reduced ability to opsonize bacteria and generate ROS. |
CD16bright/CD62Ldim |
Hypersegmented neutrophil identified in human experimental models of endotoxemia. |
Increased capacity to produce ROS and suppress T cell proliferation. |
Low density granulocytes (LDGs) |
Colocalize with mononuclear cells upon density gradient separation. Identified and characterized in various infectious and autoimmune diseases, notably systemic lupus erythematosus. |
Pro-inflammatory neutrophil with enhanced propensity to form NETs |