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. Author manuscript; available in PMC: 2017 Aug 25.
Published in final edited form as: J Phys Chem B. 2016 May 6;120(33):8264–8275. doi: 10.1021/acs.jpcb.6b01950

Figure 5.

Figure 5

(A) Sequence alignment of cTnC for protein sequences from rat and human, highlighting the conserved DCM mutations (green box) and two residue difference (red box) in N-terminus lobe of cTnC. (B) Standardized steady-state force-pCa relationship at 27°C, 25°C, 20°C and 15°C (data extracted from35). (C) Steady-state force-pCa curve simulation (solid black trace) fit to standardized force-pCa relationship (solid black dots) for rat myofilaments at 27°C (300K).