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. Author manuscript; available in PMC: 2017 Aug 25.
Published in final edited form as: J Phys Chem B. 2016 May 6;120(33):8264–8275. doi: 10.1021/acs.jpcb.6b01950

Table 3.

Parameters in six-state Markov model of myofilament activation for WT, D75Y–cTnC, E9D–cTnC and G159D–cTnC rat cardiac myofilaments at 300K steady-state force-pCa relationship for a cutoff angle of 110°.

Parameter WT D75Y E59D G159D G159D (cTnC-cTnI
interaction)
kCa+ [1/(µM *
ms)]		 0.14 0.005 0.012 0.001 0.001
kCa− (1/ms) 0.25 0.25 0.25 0.25 0.25
kpr+ (1/ms) 5699.432425 26435.49272 27055.76642 1337.311851 1337.311851
kpr− (1/ms) 19500 19500 19500 19500 19500
kIC+ [1/(µM *
ms)]		 0.01 0.01 0.01 0.01 0.01
kIC− (1/ms) 0.08 0.08 0.08 0.08 3.87E-04
kB+ (1/ms) 18 18 18 18 18
kB− (1/ms) 0.04 0.04 0.04 0.04 0.04
fXY(1/ms) 0.041837669 0.041837669 0.041837669 0.041837669 0.041837669
gXY(1/ms) 0.01891771 0.01891771 0.01891771 0.01891771 0.01891771
γB 80 80 80 80 80
γM 75 75 75 75 75
µM 46 46 46 46 46