Table 3.
Studies using Hypo-RT with similar equivalent doses.
| Studies | Patients | Dose/fraction | EQ2 for a/b 1.4 | Grade 2 ≥late GI/GU toxicity (%) |
|---|---|---|---|---|
| Arcangeli et al.9 | 168 patients randomized for Hypo-RT or Conv-RT | Arm I: 80 Gy/2 Gy/40 fx ArmII: 62 Gy/3.1 Gy/20 fx |
Hypo-RT arm: 82.1 |
RTOG GI: 14% GU: 11% |
| Patel et al.16 | 129 patients from a retrospective cohort with low risk treated with 3D-CRT and IGRT with daily ultrasound. | 3 Gy/22 fx | 85.4 |
CTC 3.0 GI: 25% GU: 32% |
| Pollack et al.7 | 307 patients randomized for Hypo-RT or Conv-RT with IMRT | Arm I: 76 Gy/2 Gy/28 fx Arm II: 70.2 Gy/2.7 Gy/26 fx |
84.7 |
RTOG GI: 6% GU: 18.5% |
| Kupelian et al.18 | 770 patients for Hypo-RT with IMRT | 70 Gy/2.5 Gy/28 fx | 80.2 |
RTOG GI: 4.5% GU: 5.2% |
| Present study | 149 patients from a retrospective cohort of patients treat with 3D-CRT | 69 Gy/23 fx | 89.2 |
RTOG GI: 13.4% GU: 14% |