Figure 5.

Filamin unfolding. Force-dependent unfolding rates $k\left(F\right)$ of the filamin domain ddFLN4 from AFM measurements (4) (green squares) when pulled from its two termini. Fits of $k\left(F\right)$ are shown as lines for μ = 0 (blue), 1/2 (red), 2/3 (magenta), and the completely brittle Bell model (3) (light green). (Inset) The error ${\chi }^2$ relative to the best fit as a function of brittleness μ, with restricted prefactor, $1<k_{\text{pre}}^{-1}<100\mu \text{s}$ (orange), and without restriction on $k_{\text{pre}}$ (green). Minimum activation barriers of $\Delta G^{‡}\left(F\right)\ge 1k_{\text{B}}T$ were imposed over the entire force range, $0<F<F_{\text{max}}=91$ pN. To see this figure in color, go online.