Fig. 3.
Adenosine 2A receptor (A2AAR) stimulation inhibits proinflammatory cytokine release. The effect of a well-known A2AAR agonist (CGS-21680; 100 nM and 1 μM) and antagonist (SCH 442416; 1 μM) on (a) interferon (IFN)-α, (b) tumor necrosis factor (TNF)-α, (c) interleukin (IL)-6, and (d) IL-1β release in cultured lymphocytes of patients with systemic lupus erythematosus (SLE) (n = 20) and healthy subjects (n = 20) that were stimulated by 0.1 mg/ml lipopolysaccharide (LPS) as determined by enzyme-linked immunosorbent assay. Data are expressed as the mean ± SEM of three independent experiments performed in triplicate * p < 0.01 versus LPS-treated cells by one-way analysis of variance with Dunnett’s test