Table 5.
Summary of results following treatment of A2780cisR cell line with CS administered in two aliquots with 2 h time gap
| Cytotoxic effect | Cellular accumulation | DNAbinding | Proteomicsa | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fresh | Aged | Fresh | Aged | Fresh | Aged | Fresh | Aged | |||
| CS + CS | ||||||||||
| 2 h | Antagonistic | Synergistic | Unchanged | Increased | Increased | Greater increase |
COF2
MARE1 NPM ANXA1 RSSA ACTB CALU HNRPF ATPA HNRPK CH60 TCPQ GLU2B HSP74 HNRPC CALR VIME |
(D,R), (D,R), (D,R), (D,R), (U,R), (U,R), (U,OR), (D,R), (U,OR), (U,OR), (U,OR), (D,OR), (U,OR), (D,OR), (U,R), (U,R), (U,OR). |
COX5A
COF2 1433γ MARE1 NPM ANXA1 HNRPF ENOA ATPA PDIA3 TCPQ GRP75 HNRPC CALR |
(D,OR), (D,OR), (D,OR), (D,OR), (D,OR), (D,OR), (D,OR), (D,R), (U,OR), (D,R), (D,R), (D,R), (U,R), (U,OR). |
aThe proteins listed have been fully/over restored in A2780cisR due to the selected combinations as compared to the parent A2780 cell line. Keys: U = up-regulated, D = down-regulated, OR = over-restored, R = fully-restored