Table 4.
Clinicopathological characteristics of the 12 patients in the validation set
| Non-relapse | Relapse | p value | |
|---|---|---|---|
| Case number | 8 | 4 | |
| Age (mean ± SD) | 63.0 ± 10.3 | 66.7 ± 8.0 | 0.425 |
| Gender | |||
| Male | 4 | 4 | 0.08 |
| Female | 4 | 0 | |
| Tumor location | |||
| Upper/middle thoracic | 5 | 2 | 0.67 |
| Lower thoracic | 3 | 2 | |
| Histological grade | |||
| Well/moderate | 7 | 2 | 0.16 |
| Poorly | 1 | 2 | |
| Pathologic tumor depth | |||
| T1-2 | 2 | 1 | 1.00 |
| T3-4 | 6 | 3 | |
| Lymph node metastasis | |||
| N0 | 3 | 1 | 0.66 |
| N1-3 | 5 | 3 | |
| Distant metastasis | |||
| M0 | 8 | 4 | - |
| M1 | 0 | 0 | |
| TNM stage | |||
| 1–2 | 3 | 1 | 0.66 |
| 3–4 | 5 | 3 | |
| Lymphatic vessel invasion | |||
| Negative | 3 | 1 | 0.66 |
| Positive | 5 | 3 | |
| Venous invasion | |||
| Negative | 2 | 1 | 1.00 |
| Positive | 6 | 3 | |
| Curability | |||
| R0 | 8 | 4 | – |
| R1 | 0 | 0 | |
| Preoperative chemotherapy | 5 | 3 | – |
| Preoperative CRT | 0 | 0 | |
| Postoperative chemotherapy | 2 | 3 | – |
| Postoperative CRT | 0 | 0 | |
| Observation period (month, mean ± SD) | 64.6 ± 18.3 | 51.1 ± 33.6 | 0.049 |
| Duration between surgery and tumor relapse | – | 8.8 ± 2.9 | – |
| Type of tumor relapse | |||
| Liver (H) | 0 | 2 | |
| Lymph node (Ly) | 0 | 2 | |
| miR-574-3p (<0.7) | 1 | 3 | 0.029 |
| miR-574-3p (≥0.7) | 7 | 1 | |
| miR-106b (<1.00) | 1 | 1 | 0.576 |
| miR-106b (≥1.00) | 7 | 3 | |
| miR-1303 (<1.20) | 5 | 2 | 0.576 |
| miR-1303 (≥1.20) | 3 | 2 | |