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. 2016 Aug 26;16(1):103. doi: 10.1186/s12876-016-0520-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Immunolocalization of ST2 in colonic tissue from responder and non-responder patients during baseline and 6-month follow-up. a Total ST2 immunoreactivity was restricted to the cellular infiltrate in the lamina propria at 6 months in responder patients (right), while in patients showing reactivation, total ST2 was increased in inflamed mucosa, also confined to the cellular infiltrate (left); baseline examination revealed extensive immune cell infiltration of the intestinal mucosa and damaged tissue with loss of architecture. b Total ST2 immunoreactivity at 6 months expressed as arbitrary units (A.U.) and normalized to baseline levels in responders and non-responders (n = 4 in each group) was higher in the non-responders. Hoechst 33342/ ST2 (blue/green) (60X)