Table 4.
Characteristics of included studies
| Authors & Year | Species & sex (no.) | Sex | Type of mode | Drug (treated/control) | Main experimental groups | Dose of administration | Method/Time of TSG administration | Quality score | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| Zhang et al. 2006 [17] | PDAPPV717I transgenic mouse (72) | Female & Male | Transgenic model | TSG/water | 1) AD plus water | 120 (TSG -L), & 240 (TSG-H) mg/kg body wt | Intragastrically/4 months | 7 | MWM |
| 2) AD plus TSG -L | |||||||||
| 3) AD plus TSG-H | |||||||||
| Zhou et al. 2012 [13] | Sprague-Dawley rat (n = 12) | Male | Aβ infused rats | TSG/NS | 1) AD plus NS | 25 mg/kg body wt | Intragastrically/4 months | 7 | MWM |
| 2) AD plus TSG | |||||||||
| Zhang et al. 2006 [27] | PDAPPV717I transgenic mouse (53) | Female & Male | Transgenic model | TSG/water | 1) AD plus water | 50 mg (TSG -L), 100 mg (TSG -M),& 200 mg (TSG-H) g/kg body wt | Intragastrically/4 months | 6 | MWM |
| 2) AD plus TSG -L | |||||||||
| 3) AD plus TSG -M | |||||||||
| 4) AD plus TSG-H | |||||||||
| Xing et al. 2006 [28] | PDAPPV717I transgenic mouse (46) | Female & Male | Transgenic model | TSG/water | 1) AD plus water | 0.05 (TSG -L), & 0.20 (TSG-H) g/kg body wt | Intragastrically/6 months | 6 | MWM |
| 2) AD plus TSG -L | |||||||||
| 3) AD plus TSG-H | |||||||||
| Xie et al. 2005 [29] | BALB/c mouse (n = 12) | Female | D-galactose infused mice | TSG/water | 1) AD plus water | 0.05 g/kg body wt | Intragastrically/2 months | 4 | MWM |
| 2) AD plus TSG | |||||||||
| Chu et al. 2005 [30] | Balb/c mouse (n = 52) | Female | D-galactose infused mice | TSG/water | 1) AD plus water | 33 mg (TSG-L), 100 mg (TSG-M),& 300 mg (TSG-H) g/kg body wt | Intragastrically/2 months | 6 | MWM |
| 2) AD plus TSG -L | |||||||||
| 3) AD plus TSG -M | |||||||||
| 4) AD plus TSG-H | |||||||||
| Huang et al. 2008 [31] | Kunming mouse (n = 40) | Female & Male | D-galactose Infused mice | TSG/water | 1) AD plus water | 33 mg (TSG-L), 100 mg (TSG-M),& 300 mg (TSG-H) g/kg body wt | Intragastrically/2 months | 5 | MWM |
| 2) AD plus TSG –L | |||||||||
| 3) AD plus TSG –M | |||||||||
| 4) AD plus TSG-H | |||||||||
| Huang et al. 2008 [32] | SMAP mouse | Male | Transgenic model | TSG/NS | 1) AD plus NS | 33 mg (TSG-L), 100 mg (TSG-M),& 300 mg (TSG-H) g/kg body wt | Intragastrically/50 days | 5 | MWM |
| 2) AD plus TSG –L | |||||||||
| 3) AD plus TSG –M | |||||||||
| 4) AD plus | |||||||||
| TSG-H | |||||||||
| Liu et al. 2012 [33] | SMAP mouse | Male | Transgenic model | TSG/NS | 1) AD plus NS | 33 mg (TSG-L), 100 mg (TSG-M),& 300 mg (TSG-H) g/kg body wt | Intragastrically/50 days | 6 | MWM |
| 2) AD plus TSG –L | |||||||||
| 3) AD plus TSG –M | |||||||||
| 4) AD plus TSG-H | |||||||||
| Chu et al. 2004 [34] | Balb/c mouse (n = 52) | Female | Aβ infused mice | TSG/NS | 1) AD plus NS | 0.1 g/kg body wt | Intragastrically/8 weeks | 5 | MWM |
| 2) AD plus TSG | |||||||||
| Ye et al. 2003 [35] | Sprague-Dawley rat (n = 43) | Male | ibotenic acid infused rats | TSG/NS | 1) AD plus water | 30 mg (TSG-L), 60 mg (TSG-M),& 120 mg (TSG-H) g/kg body wt | Intraperitoneally/1 month | 5 | MWM |
| 2) AD plus TSG -L | |||||||||
| 3) AD plus TSG -M | |||||||||
| 4) AD plus TSG-H | |||||||||
| Ye et al. 2005 [36] | Sprague-Dawley rat (n = 29) | Male | scopolamineinfused rats | TSG/NS | 1) AD plus water | 33 mg (TSG-L) & 100 mg (TSG-H) g/kg body wt | Intraperitoneally/2 months | 6 | MWM |
| 2) AD plus TSG -L | |||||||||
| 3) AD plus TSG-H | |||||||||
| Wang et al. 2007 [12] | Sprague-Dawley rat | Male | Aged rats | TSG/water | 1) AD plus water | 30 mg(TSG-L), 60 mg (TSG-M) g/kg body wt | Intragastrically/12 W | 6 | PWM |
| 2) AD plus TSG -L | |||||||||
| 3) AD plus TSG-H | |||||||||
| Luo et al. 2009 [15] | Sprague-Dawley rat | Male | aluminum chloride exposure rats | TSG/water | 1) AD plus water | 4000 mg g/kg body wt | Intragastrically/20 W | 7 | PAT |
| 2) AD plus TSG | |||||||||
| Hou et al. 2011 [40] | Sprague-Dawley rat | Male | Aged rats | TSG/NS | 1) AD plus NS | 50 mg g/kg body wt | Intragastrically/20 W | 7 | MWM |
| 2) AD plus TSG | |||||||||
| Luo et al. 2010 [37] | Sprague-Dawley rat | Male | Aβ infused rats | TSG/NS | 1) AD plus NS | 100 mg g/kg body wt | Intragastrically/3 W | 5 | YEM |
| 2) AD plus TSG | |||||||||
| Zhao et al. 2004 [38] | Wistar rat | Male | Hypercholestero-lemia rats | TSG/NS | 1) AD plus NS | 30 mg (TSG-L), 60 mg (TSG-M),& 120 mg (TSG-H) g/kg body wt | Intragastrically/10 W | 7 | MWM |
| 2) AD plus TSG -L | |||||||||
| 3) AD plus TSG -M | |||||||||
| 4) AD plus TSG-H | |||||||||
| Luo et al. 2012 [39] | Sprague-Dawley rat | Male | Aβ infused rats | TSG/NS | 1) AD plus NS | 50 mg g/kg body wt | Intragastrically/3 W | 4 | YEM |
| 2) AD plus TSG |
MWM Morris water maze test, PWM Passageway water maze, PAT Passive avoidance task, YEM Y maze experiment