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. 2016 Aug 26;13(1):203. doi: 10.1186/s12974-016-0687-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Effect of EFX treatment on CCI-induced microglia/macrophage activation in rats 2 days post-injury. EFX (50 mg/kg, i.p.) or its vehicle were administered 30 min after surgery and 24 h after (n = 5/group). Microglia/macrophage activation was evaluated with CD68 immunostaining. TBI induced an increase in CD68 immunoreactivity in the ipsilateral side of the injury (p < 0.001). EFX treatment significantly reduced microglia/macrophage activation (p < 0.001) in injured animals in comparison with vehicle treatment. Images show representative sections from each group (ipsilateral and contralateral side). Data are mean + SEM. ^### p < 0.001: comparison between sham-vehicle and TBI-vehicle groups; ***p < 0.001: comparison between TBI-vehicle and TBI-EFX groups