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. Author manuscript; available in PMC: 2016 Aug 27.
Published in final edited form as: Neuroscientist. 2014 Nov 21;22(1):46–60. doi: 10.1177/1073858414558065

Figure 3.

Figure 3

Male gonadectomized rats exhibit increased mossy fiber transmission, paired pulse facilitation, and LTP. (A) Increasing stimulus strength to the mossy fibers produced field EPSPs (fEPSPs) with increasing slope and amplitude, recorded in stratum lucidum. Responses to stimuli are plotted for all sham (black circles) and gonadectomized (white) rats. Repeated-measures ANOVA showed that there was a significant effect of gonadectomy, and post hoc tests showed that most individual comparisons were significantly different (asterisks above the symbols). (B) Responses are shown for sham and gonadectomized rats with the recording electrode positioned in the pyramidal cell layer. Population spike amplitude was significantly larger in gonadectomized rats. (C) Recording electrodes were placed in stratum lucidum to examine paired pulse facilitation. Analysis of paired pulse facilitation with a range of interstimulus intervals from 20 to 200 ms showed that there was a significant effect of gonadectomy at intermediate intervals. (D) Comparison of LTP in gonadectomized (white circles) and sham rats (black circles) illustrates greater LTP in gonadectomized rats. Insets: representative examples of fEPSPs before and after LTP induction, with LTP evident only in the slice from the gonadectomized rat. Data from Skucas and others (2013).