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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Hum Genet. 2016 Jun 8;135(9):1071–1082. doi: 10.1007/s00439-016-1686-2

Fig. 1.

Fig. 1

Generation of endonuclease-resistant virus. Upon endonuclease cleavage of an essential viral gene the DNA double strand break can be repaired perfectly (A), mutated to yield a replication incompetent virus (B), mutated to yield a treatment-resistant virus (C), or treated with a second endonuclease to prevent treatment resistance (D)