Table 1.

Characteristics of viral vectors targeting T cells, macrophages, dendritic cells, hematopoietic stem cells for HIV-1 gene therapy¹.

Gene therapy characteristics	Adenoviral vector	Lentiviral vector	Adeno-associated viral vector
Tissue tropism	proliferating and non-proliferating cells	proliferating and non-proliferating cells	proliferating and non-proliferating cells
Packaging capacity	7-35 kb	8 kb	4.5 kb
Relative delivery efficiency	high	very high	high
Gene expression level	transient	stable	stable or transient
Integration site	2N/A	random site	AAVS1 site in chromosome 19
Immunogenicity	high	low	negligible
Pseudotyped with	Ad5/35 fiber	3VSV- glycoprotein	2N/A
Receptors	CD46	4LDL receptor	Heparin sulfate proteoglycan (serotype 2)

¹Table adapted from (Schroers et al. 2004; Zhang et al. 2013; Ayuso 2016; Summerford and Samulski 1998; Finkelshtein et al. 2013).

²Not applicable.

³Vesicular stomatitis virus.

⁴Low density lipoprotein.