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Details of SPMS and healthy control individuals
| Next generation sequencing | Replication cohort | |||
|---|---|---|---|---|
| SPMS | HC | SPMS | HC | |
| Number | 12 | 12 | 12 | 10 |
| Female | 9 | 9 | 8 | 5 |
| Age in years (mean ± SD) | 60.2 ± 8.3 | 61.3 ± 9.5 | 61.4.0 ± 6.5 | 60.1 ± 5.9 |
| EDSS (mean ± SD) | 6.9 ± 0.9 | NA | 5.9 ± 1.0 | NA |
| Active SPMS | 3 | NA | 4 | NA |
| Disease duration in years (mean ± SD) | 25.6 ± 11.1 | NA | 18.3 ± 6.5 | NA |
| Progression duration (mean ± SD) | 10.8 ± 8.1 | NA | 8.9 ± 6.2 | NA |
EDSS expanded disability status scale, SD standard deviation, NA not applicable
