TH-ligand interactions. The six interacting residues of the receptor are shown in “stick” format and the ligands are represented in “net” format. Interacting amino acid residues are colored as follows: Leu 324, red; Phe 330, purple; His 361 and His 366, yellow; Tyr 401, green; Glu 406, cyan. Zn+2 are shown as a violet ball. Ligands are shown in different colors: PPCA, L-tyrosine in pink, L-DOPA in yellow, norepinephrine in cyan, and epinephrine in green. (A) Front view, (B) rear view, (C) right side view, (D) left side view.