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The anti-malarial compound artesunate blocks hypertrophy of cultured NRVMs. (A) Chemical structure of artesunate. (B) Quantitative high content imaging demonstrates dose-dependent inhibition of PMA-mediated NRVM hypertrophy and ANF expression by artesunate, with sub-micromolar IC50 values for each endpoint. (C) Representative images of NRVMs treated with PMA in the absence or presence of artesunate.
