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. Author manuscript; available in PMC: 2016 Aug 29.
Published in final edited form as: J Huntingtons Dis. 2016;5(1):65–81. doi: 10.3233/JHD-150181

Fig. 1.

Fig. 1

A. sIPSCs were recorded at a holding potential of +10mV from visually identified MSNs in the dorsal striatum from symptomatic R6/2 mice (>70 days of age). In regular ACSF cells displayed high frequency, large amplitude sIPSCs. Incubation with cholesterol resulted in a significant reduction of large amplitude currents. B. The average frequency of sIPSC was practically unchanged by incubation in cholesterol (inset). There was a trend towards reduced medium- and large-amplitude synaptic events (amplitudes larger than 30 pA). C. In agreement, the cumulative amplitude histogram demonstrated a significant leftward shift indicating a decrease in large amplitude events or proportionately more low-amplitude events [two-way RM ANOVA, F(6,150)=13.782, p<0.001]. Asterisks indicate bins with statistically significant differences after Bonferroni post-hoc test. In this and subsequent figures * p<0.05, ** p<0.01 and *** p<0.001. D. The cumulative inter-event interval (IEI) probability distribution did not show a significant difference.